For those just wanting details of where I went for the poop transplant, the IPPM clinic details can be found by scrolling all the way down.

In a nutshell: I have suffered well over a decade of abdominal pains, but only at night. Undoubtedly caused by a chronic herpes infection affecting the nerve that governs the gut. I had it under control and was doing well. Then, in April 2020, I got COVID, and it messed me up completely for 15 months (“long COVID”), and despite recovering from COVID, my gut issues never settled down.

During this time, I discovered by chance that the antihistamine and over-the-counter “sleeping medication” diphenhydramine (sold in the UK as Nytol and in the USA as Benadryl) eliminated the gut problem completely as long as I kept taking it. But long-term consumption of diphenhydramine is really bad and is connected to all sorts of neurological disorders.


Cumulative Use of Strong Anticholinergics and Incident Dementia.
A Prospective Cohort Study

Shelly L. Gray, PharmD, MS; Melissa L. Anderson, MS; Sascha Dublin, MD, PhD; et al.

“The general view is that anticholinergic-induced cognitive impairment is reversible on discontinuation of medication therapy. However, several investigators have reported that anticholinergics may be associated with an increased risk for sustained cognitive deficits, such as mild cognitive impairment or dementia.”

More: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2091745


In researching why this should eliminate my abdominal pain, I learned about mast cell activation.

Have you been told you have irritable bowel syndrome (IBS), either IBS-C (constipation) or IBS-D (the messier version)?

Then there are three words you want to start Googling in a frenzy. MAST CELL ACTIVATION

Here’s a quick summary of mast cells for you:

  1. You got them everywhere in the body.
  2. They are the cells that contain all that lovely histamine that will make you itch like hell when triggered by a triggering thing.
  3. Antihistamines inhibit these cells from releasing their histamine.
  4. You got a shit-load of them in your intestines.
  5. Many foods will trigger them, especially fermented foods and foods high in nitrites (sausages, burgers, and fish that aren’t fresh—basically anything that comes out of a tin or is preserved or processed in some way).
  6. This in turn causes neurogenic inflammation, visceral hypersensitivity, and impaired peristalsis.

I’ve lost count of how many healthcare professionals I’ve seen, and literally no one ever mentioned this. I was just told to destress and take antidepressants, go away, and stop being annoying by being so persistently symptomatic.

Let me translate that line 6 for you.
Histamine reactions in the gut cause nerve swelling, sensitivity, and lack of muscular function in the intestines. AKA: painful bloating and painful constipation.


The relationship between mucosal inflammatory cells, specific symptoms, and psychological functioning in youth with irritable bowel syndrome

Meenal Singh, Vivekanand Singh, Jennifer V. Schurman, Jennifer M. Colombo & Craig A. Friesen.

…Mast cells have been highly implicated in IBS pathogenesis in both IBS-C and IBS-D. IBS has been associated with an increase in the density of degranulating mast cells, while the density of mast cells in close proximity to enteric nerves correlates with abdominal pain severity…

More: https://www.nature.com/articles/s41598-020-68961-9


So, I began googling and googling. I was already aware of poop transplants and the role of the gut microbiota.

Do this later: Type the following words into Google and start studying:
Mast cell IBS fecal microbiota transplantation

Luckily, they don’t actually transplant the poop, but instead it’s just the cultures taken from the poop. So it’s all proper medical and everything.

There are several delivery methods – basically, you either swallow capsules containing the “ingredients”, or you get a small hosepipe up the butt and it is squirted in.

Typically the poop cultures are taken from 10 different healthy and fully screened donors (the screening is extensive, lengthy, and very thorough).


Arrival in Slovakia


Bowel prep the day before the first FMT implantation


First Implantation Completed


Second Implantation Completed


What’s that Smell???? The third implantation completed


Day 4: Fecal Microbiota Implantation – more Q&A


Infection Response – Not too well after day 5


Day 6 – Huge Improvement and Problems with “The FMT Community”


Days 7 and 8 – Discombobulation and mast cell activation


Implant 9 completed. Doing GREAT!


All poop implants finished! I can go home.

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Top Tips for your poop transplant at IPPM.

Accommodation:

  1. Choose accommodation that is close to the clinic.
  2. You might not want to walk much after implants.
  3. There is a Lidl opposite.
  4. Bring earplugs.
  5. Town centre is ~20 minutes away.
  6. Bring entertainment.
  7. Bring laundry detergent.
  8. The big Tesco has an excellent pharmacy.
  9. ENGLISH PEOPLE: Bring your own tea bags.

The IPPM Clinic – The Institute of Predictive and Personalized Medicine

Odbojárov 300/4, 955 01, Tovarníky (Topoľčany), Slovakia.

Tel: +421 911 212 838

Website:

https://www.ippmclinic.com/

Facebook:

https://www.facebook.com/ippm.sk/


The comments section is open below. Please share your experiences there.

Please note:

  1. I cannot advise you if this treatment will work for you.
  2. I cannot help plan your travel.
  3. Please don’t ask if it helped — that has already been answered.
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Nik
4 years ago

Thanks for the video’s. They are very informative. I’m seriously considering checking this procedure out.

Lucy
4 years ago

Could you tell us if the treatment has made any changes in your health condition?

Thanks
Lucy

Daniel
4 years ago

Hey Andrew, thank you so much for sharing all these details – it is so helpful! Would you mind giving a short update if this treatment was successful for you? I am considering having a FMT at the IPPM as well… Best Regards Daniel

Daniel
4 years ago

Thank you so much for the update!

Karolien Taverniers
2 years ago

Dear Andrew, Could you tell me more about your remarkable mood change?

Ross Collins
2 years ago

I heard a woman on my Facebook group talking about how she had 2 failed FMT treatments and couldn’t work out the problem. A doctor reached out to her and suggested that instead of a colonoscopy, she takes the oral FMT. She did this and very quickly cured her c diff. So by targeting the small intestine as opposed to the large intestine, she fixed the problem. It’s something to consider at least.

Cap
2 years ago
Reply to  Ross Collins

Dear Andrew,

Thanks For Posting Your Story! I Want To Ask You if After All The Treatment You Really Good Better (maybe for just a while?) Or if, after all, You Haven’t noticed Any Difference In Your Gut Health and you’re still having a lot of problems with it.

Thank you! 😊

Cap
2 years ago
Reply to  Ross Collins

Do you know where did she take this treatment? Thanks in advance!

Cap
2 years ago

Dear Andrew,

Thanks For Posting Your Story! I Want To Ask You if After All The Treatment You Really Good Better (maybe for just a while?) Or if, after all, You Haven’t noticed Any Difference In Your Gut Health and you’re still having a lot of problems with it.

Thank you! 😊

Sarah
2 years ago

Hi Andrew, thanks so much for all the info. You mentioned on YouTube that you’d heard it could be up to a year before noticing any improvement in gut health. Now that it’s been a couple of years, have there been any further changes?

Has the mood improvement lasted?

Despite the failure to get improvement to your gut (unless that improvement did come sometime later), would you say it was worth it?

Sarah Voorhies
2 years ago

One more quick question and I apologize if I’m being a pest:

I’ve heard that IPPM formerly sourced their FMT material from Taymount, but then switched to using local Slovakian donors. Do you know whether they were using local donors or Taymount samples when you got your treatment?

Thanks, Andrew. I appreciate your sharing your story.